The effect of neurodegenerative diseases on the subventricular zone
Identifieur interne : 000F38 ( Main/Exploration ); précédent : 000F37; suivant : 000F39The effect of neurodegenerative diseases on the subventricular zone
Auteurs : Maurice A. Curtis [Suède] ; Richard L. M. Faull [Nouvelle-Zélande] ; Peter S. Eriksson [Suède]Source :
- Nature Reviews Neuroscience [ 1471-003X ] ; 2007-09.
Abstract
During brain development, one of the most important structures is the subventricular zone (SVZ), from which most neurons are generated. In adulthood the SVZ maintains a pool of progenitor cells that continuously replace neurons in the olfactory bulb. Neurodegenerative diseases induce a substantial upregulation or downregulation of SVZ progenitor cell proliferation, depending on the type of disorder. Far from being a dormant layer, the SVZ responds to neurodegenerative disease in a way that makes it a potential target for therapeutic intervention.
Url:
DOI: 10.1038/nrn2216
Affiliations:
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